Novel Insights into Impairment of Membrane Integrity by Alpha-Synuclein Oligomers
نویسندگان
چکیده
منابع مشابه
α-Synuclein Oligomers Induced by Docosahexaenoic Acid Affect Membrane Integrity
A key feature of Parkinson disease is the aggregation of α-synuclein and its intracellular deposition in fibrillar form. Increasing evidence suggests that the pathogenicity of α-synuclein is correlated with the activity of oligomers formed in the early stages of its aggregation process. Oligomers toxicity seems to be associated with both their ability to bind and affect the integrity of lipid m...
متن کاملKinetic measurements give new insights into lipid membrane permeabilization by α-synuclein oligomers.
Interactions of oligomeric aggregates of the intrinsically disordered protein α-synuclein with lipid membranes appear to play an important role in the development of Parkinson's disease. The permeabilization of cellular membranes by oligomers has been proposed to result in neuronal death. The detailed mechanisms by which α-synuclein oligomers permeabilize lipid bilayers remain unknown. Two diff...
متن کاملModelling Ser129 Phosphorylation Inhibits Membrane Binding of Pore-Forming Alpha-Synuclein Oligomers
BACKGROUND In several neurodegenerative diseases, hyperphosphorylation at position Ser129 is found in fibrillar deposits of alpha-synuclein (asyn), implying a pathophysiological role of asyn phosphorylation in neurodegeneration. However, recent animal models applying asyn phosphorylation mimics demonstrated a protective effect of phosphorylation. Since metal-ion induced asyn oligomers were iden...
متن کاملDirect detection of alpha synuclein oligomers in vivo
BACKGROUND Rat models of Parkinson's disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alph...
متن کاملAlpha-Synuclein Oligomers Cellular Mechanisms and Aspects of Antibody Treatment
Gustafsson, G. 2017. Alpha-Synuclein Oligomers. Cellular Mechanisms and Aspects of Antibody Treatment. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1344. 64 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-513-0008-5. In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Sma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.1413